The suppression of HORIUCHI H-FUCOIDAN and L-FUCOIDAN on the growth of cancer cells was confirmed.

April 22, 2021
FCC Horiuchi Co., Ltd.

FCC Co., Ltd. Horiuchi (Representative Director; Yoshihiro Horiuchi, Location: Kurume City, Fukuoka Prefecture) has collaborated with Graduate school of Kyushu University (Faculty of Agriculture, Department of Agro-Environmental Sciences, Division of Sustainable Bioresources Science, Associate Professor Kuniyoshi Shimizu). An evaluation test was conducted on the cancer cell growth inhibitory effect using HORIUCHI *H-FUCOIDAN and HORIUCHI *L-FUCOIDAN.

* H-FUCOIDAN is high molecular weight fucoidan, L-FUCOIDAN is low molecular weight fucoidan.

In order to evaluate how each fucoidan affects the growth of normal cells and cancer cells, human normal colon cells (CCD841) were used as normal cells.Human colon cancer cells (CaCo-2), human breast cancer cells (MCF-7) and human gastric cancer cells (MKN45) were used as cancer cells.

As a result, both H-FUCOIDAN and L-FUCOIDAN promoted growth of normal human colon cells (CCD841) (see graph *1), whereas human colon cancer cells (CaCo-2), and human breast cancer cells (MCF-7) were suppressed their growth (see graphs *2 and *3).

CCD841 (human normal colon cells)

[Graph *1] Data were provided by Kyushu University

CaCo-2 (human colon cancer cells)

[Graph *2] Data were provided by Kyushu University

MCF-7 (human breast cancer cells)

[Graph *3] Data were provided by Kyushu University

These results suggest that, H-FUCOIDAN and L-FUCOIDAN can be expected to have anticancer activity that activate normal cells and selectively suppress the growth of cancer cells. This is a very interesting result.

In addition, when H-FUCOIDAN was added to human gastric cancer cells (MKN45) at the same time with cell seeding, the adhesion of the cancer cells was inhibited. Normally, when cancer cells metastasize, they proliferate by adhering to a new location, but this data suggests that cancer cells may be prevented from metastasizing and adhering (see graph *4).

[Graph *4] Data were provided by Kyushu University

In H-FUCOIDAN, growth suppression of human gastric cancer cells (MKN45) was observed compared with the control. In addition, cell adhesion to the petri dish could hardly be seen under microscope.

H-FUCOIDAN can be expected to have anticancer activity for suppressing cell proliferation and metastasis if co-processed with MKN45 cells.

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